Research Library

Peer-reviewed studies and scientific evidence

Every product we develop at Peak Revival-X is informed by peer-reviewed research. This library contains the key studies that guide our formulations and recommendations.

Creatine Research
3 studies
International Society of Sports Nutrition position stand: creatine supplementation and exercise
Kreider RB, Kalman DS, Antonio J, et al. • Journal of the International Society of Sports Nutrition (2017)
creatine

This comprehensive position stand reviews the scientific literature on creatine supplementation, concluding that creatine monohydrate is the most effective ergogenic nutritional supplement currently available to athletes for increasing high-intensity exercise capacity and lean body mass during training.

Key Findings:

  • Creatine monohydrate is the most extensively studied and clinically effective form of creatine
  • Supplementation increases muscle creatine and phosphocreatine concentrations by 20-40%
  • Short-term supplementation improves maximal power/strength by 5-15%
  • Long-term supplementation appears to enhance the quality of training, leading to 5-15% greater gains
Effects of creatine supplementation on cognitive function: a systematic review and meta-analysis
Avgerinos KI, Spyrou N, Bougioukas KI, et al. • Experimental Gerontology (2018)
creatine

This meta-analysis examined the effects of creatine supplementation on cognitive function, finding that creatine supplementation improves short-term memory and intelligence/reasoning, particularly in aging individuals and those under stress.

Key Findings:

  • Creatine supplementation improves short-term memory
  • Benefits are more pronounced in elderly individuals
  • Cognitive benefits observed in stressed or sleep-deprived individuals
  • Safe for long-term cognitive supplementation
Creatine supplementation and lower limb strength performance: a systematic review and meta-analyses
Lanhers C, Pereira B, Naughton G, et al. • Sports Medicine (2015)
creatine

This systematic review and meta-analysis evaluated the effects of creatine supplementation on lower limb strength performance, finding significant improvements in both maximal strength and endurance.

Key Findings:

  • Creatine supplementation significantly improves lower limb strength
  • Effects observed in both trained and untrained individuals
  • Benefits seen in various exercise protocols
  • Optimal dosing: 5g daily after loading phase
Electrolyte Science
2 studies
Sodium replacement and plasma sodium drop during exercise in the heat when fluid intake matches fluid loss
Barr SI, Costill DL, Fink WJ • Journal of Applied Physiology (1991)
electrolytes

This foundational study demonstrated that sodium replacement during prolonged exercise in heat is essential for maintaining plasma sodium levels, even when fluid intake matches sweat losses.

Key Findings:

  • Water alone is insufficient for optimal hydration during prolonged exercise
  • Sodium replacement prevents hyponatremia
  • Electrolyte balance affects exercise performance
  • Sweat sodium losses vary significantly between individuals
Magnesium and exercise
Nielsen FH, Lukaski HC • Current Opinion in Clinical Nutrition and Metabolic Care (2006)
electrolytes

This review examines the relationship between magnesium status and exercise performance, highlighting that magnesium deficiency impairs exercise performance and that exercise increases magnesium requirements.

Key Findings:

  • Magnesium is essential for muscle contraction and relaxation
  • Exercise increases urinary and sweat magnesium losses
  • Marginal magnesium deficiency impairs exercise performance
  • Athletes may have increased magnesium requirements
Hydration Studies
1 studies
Fluid and electrolyte needs for training, competition, and recovery
Shirreffs SM, Sawka MN • Journal of Sports Sciences (2011)
hydration

This review provides comprehensive guidelines for fluid and electrolyte intake before, during, and after exercise, emphasizing the importance of individualized hydration strategies.

Key Findings:

  • Pre-exercise hydration should begin 4 hours before activity
  • During exercise, aim to prevent >2% body mass loss
  • Post-exercise rehydration should include sodium to retain fluids
  • Individual sweat rates and composition vary widely
Safety Data
2 studies
Long-term creatine supplementation does not significantly affect clinical markers of health in athletes
Kreider RB, Melton C, Rasmussen CJ, et al. • Molecular and Cellular Biochemistry (2003)
safety

This long-term study (21 months) examined the effects of creatine supplementation on clinical markers of health in athletes, finding no adverse effects on kidney function, liver function, or other health markers.

Key Findings:

  • No adverse effects on kidney function after 21 months
  • Liver enzymes remained within normal ranges
  • No negative effects on blood lipid profiles
  • Creatine supplementation is safe for long-term use
Creatine supplementation does not impair kidney function in type 2 diabetic patients
Gualano B, de Salles Painelli V, Roschel H, et al. • European Journal of Applied Physiology (2011)
safety

This randomized controlled trial examined creatine supplementation in type 2 diabetic patients, a population potentially at higher risk for kidney issues, finding no adverse effects on kidney function.

Key Findings:

  • No adverse effects on kidney function in diabetic patients
  • Creatine supplementation was well-tolerated
  • GFR and creatinine clearance remained stable
  • Safe for populations with metabolic conditions

Research Disclaimer

The research summaries provided here are for educational purposes only and do not constitute medical advice. Always consult with a healthcare professional before starting any supplement regimen. Peak Revival-X products are not intended to diagnose, treat, cure, or prevent any disease.

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